Louisa married a William Blockley and had a few children, here's one of her decendants...
Henry & Maria - Louisa 1837, Thomas Blockley 1872, Thomas Clifford 1902, Vera 1936, Gary Kirby 1970.
So it does look like that there's quite a few descendants out there. John, Rebecca and Louisa all died before 1881, which you may already know.